Research snippets

Here are glimpse of my scientific journey through the years, exploring diverse biological systems using experimental and data-driven approaches for understanding the mechanistic basis of biological processes.

Please read short summaries of my work here. I strongly endorse unrestricted access to science and have thrived to publish in open access and preprints. If you have problems getting hold of any of the works, please reach out, and I will be happy to send you a digital copy. Cheers, and happy sciencing!

How fascinating parasites invade their hosts

Here, we utilize cool electron microscopy methods to capture ultrafast events during which the eukaryotic parasites invade their host cells. We also show how the invasion apparatus changes during these stages and highlight probable mechanisms microsporidia use to prime themselves for initiating infection.

Please find the work here: https://www.biorxiv.org/content/10.1101/2023.05.31.543061v1

A close look at one of the smallest eukaryotic ribosomes

Here we reveal the high resolution structure of ribosomes from the microsporidia Paranosema locustae. Turns out, not only are these one of the smallest eukaryotic ribosomes known till now, these tiny ribosomes also tell fascinating tales of microsporidia ribosome evolution.

Please find the work here: https://doi.org/10.1371/journal.pbio.3000958

How bacteria ensure quality of their ribosomes?

Ribosome make proteins with a very high degree of fidelity and extensive quality control mechanisms. But, how is the quality of ribosomes themselves ensured? In this we explored that in the tiny bacterium called E. coli.

Please find the work here : https://doi.org/10.1093/nar/gkz825

Tools to track ribosome biogenesis in bacterial cells

Ribosomes make proteins in cells, but tracking their own formation is particularly tricky due to a variety of cellular and technical challenges. Here I designed a simple, fluorescence based system to asses ribosomes biogenesis in E. coli.

Please find the work here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014008/

Strategies and approaches for mechanistic understanding of bacterial ribosome assembly

I undertook several approaches to revisit the field of bacterial ribosome biogenesis. In my work, a combination of biochemical, genetic, proteomic, and transcriptomic approaches were utilised to discover factors assisting ribosome formation and also established new checkpoints in during ribosome biogenesis.

Please find the work here: http://gyan.iitg.ac.in/handle/123456789/1602

Fellowships and Awards

7. Marie Skłodowska-Curie Actions Postdoctoral fellow (Sweden)

6. Wallenberg Foundation Grant (Sweden)

5. Senior Research Fellow (India)

4. MHRD-GATE fellow (India)

3. Best Presentation, Annual Engineers Meeting, Kurukshetra University, India. September 2009.

2. Best presentation, 8th National Technical Symposium, Haryana Engineering College, India, March 2009.

1. Poster presentation prize, Seminar on Biotechnology Education and Human Resource Development, NC College of Engg, India. October 2008

Talks and presentations

7. CSSB Symposium 2023, "Charting the landscape of infection: From entry to exit". Hamburg, 3rd -5th May 2023.

6. Invited Talk, CSIR – Institute of Microbial Technology, India, 27th April 2023

5. 15th Young Investigators Meeting, IIT Gandhinagar, 13th-17th Feb 2023.

4. Bioengineering Seminar Series, Department of Biological Engineering, IIT Gandhinagar, 8th Feb 2023.

3. Nordic-EMBL partnership meeting, EMBL advanced training center, Heidelberg, 21st Sept 2022

2. Postdoctoral funding seminar Series, Research Support Office, Umeå University, Sweden, 9th Feb 2022

1. KBC days (Annual symposium), Chemical Biology Center, Umeå University, Sweden, 8th-10 Nov 2021

Poster presentations

5. 15th Young Investigators Meeting, IIT Gandhinagar, 13th-17th Feb 2023.

4. Nordic-EMBL partnership meeting, EMBL advanced training center, Heidelberg, 21st Sept 2022.

3. 9th RNA Group Meet, IIT BHU, India, October 26-28th, 2017.

2. MCB75: from Molecules to Organisms, IISC Bengaluru, India, December 11-14, 2015

1. PSI 6th Annual Meeting Proteomics from Discovery to Function, IIT Bombay, India. December 6 - 11, 2014

Other workshops and meetings

6. Basic Course in Electron Microscopy, UCEM, Umeå, February 18-20th, 2020.

5. Exploring Gene Expression Data using Transcriptome and Microarrays. India, January 23 - 25, 2017

4. 9th RNA Group Meet, IIT BHU, India, October 26-28th, 2017.

3. MCB75: from Molecules to Organisms, India, December 11-14, 2015

2. Analysis of Biological Networks, IIT Guwahati, India, November 6-7, 2012

1. Computational Aspects of Working with Genomes, IMTECH Chandigarh, India, March 27-29, 2011